強效的鉑基抗腫瘤劑。與 DNA 二核苷酸 d(pGpG) 形成細胞毒性加合物,誘導鏈內交聯(lián)。
Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.
包裝
1 g in glass bottle
25, 100, 250 mg in glass bottle
性質
Related Categories
Antibiotics, Antibiotics A to Z, Antibiotics A-F,Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,